ea0041gp120 | Neuroendocrinology | ECE2016
Treppiedi Donatella
, Mantovani Giovanna
, Peverelli Erika
, Sungkaworn Titiwat
, Zabel Ulrike
, Giardino Elena
, Lohse Martin J
, Spada Anna
, Calebiro Davide
SSTR2 is one of the main pharmacological target for GH-secreting pituitary adenomas treatment and the cytoskeletal protein FLNA plays an important role in tumor responsiveness by regulating SSTR2 expression and signaling. Single-Molecule Imaging was used to investigate the spatial distribution of FLNA-SSTR2 at the plasma membrane level and the involvement of FLNA in SSTR2 mobility, receptor clustering organization/internalization. This method is based on labeling SNAP/CLIP-tag...